The risk of cardiovascular complications is high in patients with chronic kidney disease. NGAL (neutrophil gelatinase-associated lipocalin)/lcn2 is involved in cardiac remodeling and inflammation and may play a role in the progression of cardiorenal syndrome.
The risk of cardiovascular complications is high in patients with chronic kidney disease. NGAL (neutrophil gelatinase-associated lipocalin)/lcn2 is involved in cardiac remodeling and inflammation and may play a role in the progression of cardiorenal syndrome.
🫀 🫘 Conducted in collaboration with INI-CRCT members Nicolas GIRERD,Jérémy Lagrange, Natalia Lopez and Frederic Jaisser, the authors of this study performed an analysis in wild-type rats and NGAL knockout rats after nephrectomy.
🫀 🫘 They demonstrated that cardiac perfusion was less impaired in NGAL knockout rats with chronic kidney disease than in wild-type rats. Left ventricular interstitial fibrosis was more severe in wild-type rats with chronic kidney disease than in control rats, but attenuated in NGAL knockout rats with chronic kidney disease. Levels of Gal-3, Col1 (collagen 1), Ccl2 (C-C motif chemokine ligand 2), and IL-6 (interleukin-6) were elevated in cardiac fibroblasts incubated with rNGAL.
🫀 🫘 The effects of rNGAL were attenuated by concomitant treatment with Gal-3 or Tlr4 inhibitors, suggesting that Gal-3 contributes to cardiac fibrosis and inflammation.
🫀 🫘 These experiments conclude that in rats with chronic kidney disease (CKD), NGAL was involved in cardiac remodeling via a Gal-3/Tlr4-dependent pathway, enhancing inflammation and fibrosis, and was correlated with cardiac events in the MEDIA-DHF and BIOSTAT-CHF cohorts.
🫀 🫘These experimental animal models leave prospects for the use of biomarkers with cardio-renal trophism.
Matthieu Soulié, Tania Sánchez-Bayuela, @Ixchel Lima-Posada, @Yohan Stephan, Lionel Nicol, Zohra Lamiral, Jérémy Lagrange @Adriaan Voors,Natalia Lopez-Andres, Nicolas GIRERD, @Paul Mulder, and @Frédéric Jaisser
Hypertension. 2026 Feb 17. doi: 10.1161/HYPERTENSIONAHA.125.25658. Epub ahead of print. PMID: 41700406.
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